Gugulipid® Plus Lactospore  Doctors Purest Gugulipid is a standardized extract from Commiphora mukul (2.5% Guggulsterones Z&E), and has been used to help support the maintenance of healthy levels of cholesterol and blood serum lipids. The active constituents are called Guggulsterones. Lactospore® is a shelf-stable probiotic (minimum of 100 million sporogenes per tablet) that produces the beneficial L(+) form of lactic acid in the intestines. It is synergistic with Gugulipid in healthy cholesterol maintenance.  Plant sterols such as gugulipid have been shown to be very effective in maintaining normal cholesterol levels.

Gugulipid® (Commiphora mukul extract) Gugulipid® is a standardized extract for Guggulsterones Z & E used for healthy cholesterol maintenance. It is extracted from the sap of the tree Commiphora mukul, which is found in the rough and warm lands of India. In multi centric studies performed on over 300 overweight patients, Gugulipid effectively supported healthy levels of cholesterol, total serum lipids, triglycerides, beta-lipoproteins and HDL levels1. In addition, Gugulipid may also generate energy by increasing metabolic processes.

Lactospore®   Lactospore® is a preparation containing a superior sporulated strain of lactic acid producing bacteria, Lactobacillus sporogenes. It is clinically proven beneficial in the gastro-intestinal tract. It also restores normal intestinal flora and supports healthy cholesterol levels1. These spores, on activation in the environment of the stomach, germinate and proliferate in the intestine, producing lactic acid. The unique advantages of Lactospore® include room temperature stability, compatibility with other ingredients and proven effectiveness. It produces L(+)-lactic acid only.

Gugulipid^® - Mechanism(s) of Action

The studies on gum guggul indicate that its hypolipidemic activity can be attributed to more than one mechanism.Some of the possible mechanisms include:

1. Inhibition of cholesterol biosynthesis,
2. Enhancing the rate of excretion of cholesterol,
3. Promoting rapid degradation of cholesterol,
4. Thyroid stimulation,
5. Alteration of biogenic amines
6. High affinity binding and anion exchange.

The first 3 mechanisms, inhibition of cholesterol biosynthesis, enhancing rate of excretion of cholesterol, and promoting rapid degradation of cholesterol, are related in that the end result is the elimination of cholesterol. Cholesterol is an ubiquitous and important compound that is an essential component of mammalian cell membranes. It is a precursor of bile acids, steroid hormones, and vitamin D. Since cholesterol is readily synthesized in most tissues of the human body, it is not a dietary essential.

In normal human adults, the largest amounts of cholesterol are found in the liver (0.3%), skin (0.3%, related to vitamin D formation), brain and nervous tissue (2.0%), intestine (0.2%) and certain endocrine glands (related to steroid hormone biosynthesis, adrenal glands contain approx. 10%). Approximately 50% of the myelin sheath (surrounds and insulates nerves) is cholesterol that is related to proper nerve conduction and normal brain function. It has been estimated that a 71 kg adult male has approximately 75 to 150 g of cholesterol in his body.

Nearly 50% of the cholesterol produced daily is converted to bile acids and secreted as bile salts in bile. Most of it is reabsorbed and reused via enterohepatic circulation. A portion of the cholesterol that remains (approx. 0.5 to 1 g) is used to form the steroid hormones, cell membranes, and vitamin D in the skin. Any excess cholesterol is excreted mainly in the bile and intestinal tract. Also, a small amount is excreted via the skin as desquamated cells, sweat, and sebaceous secretions.

The recommended dose is the amount of Gugulipid^ equivalent to 25 mg of guggulsterones three times a day.