Doctors Purest ForsLean® is manufactured by a proprietary process(US Patent# 5,804,596) and is a standardized extract from the roots of the Coleus forskohlii plant, the only known plant source of forskohlin.

ForsLean^® potentially benefits not only overweight people but also those individuals who are actively involved in athletic training or body building, seeking to attain a higher lean body mass to body fat ratio.

It is strongly recommends the use of a sensible diet along with an exercise regimen of 30-45 minutes duration (at least three days a week) for effective weight management. Natural products such as ForsLean^® may enhance such measures and help to achieve the desired results.

Mechanism of action of ForsLean® in lean body mass.

As mentioned previously, forskohlin is known as a compound with versatile biological actions based on its ability to stimulate adenylate cyclase and cyclic AMP levels.

Typically, an increase in cyclic AMP leads to subsequent activation of protein kinase. Protein kinase has been shown to activate the hormone sensitive lipase which is involved in the breakdown of triglycerides, known as building blocks of fatty tissue1.

The other factor relevant to the weight loss mechanism of forskohlin involves its thyroid stimulating action, comparable in strength to thyrotropin or TSH2. The thyroid stimulating action of forskohlin may also contribute to the increase in the metabolic rate and thermogenesis.

Forskohlin may also be involved in regulating insulin secretion3. Insulin, although well recognized for its metabolism of carbohydrates, is also involved in the metabolism of fats and proteins that are major contributors to body composition.